JuniperPublishers | Annals of Reviews & Research

Protein Protein Interactions and Protein Folding as Therapeutic Targets


Authored by Eswari Beeram

The process of protein folding to native protein was one of the most peculiar processes which is ravelled by many of the anti microbial agents and genetically altered cells and getting successful by introducing loss of function or gain of function mutations related to the process. Cystic fibrosis is one of the well understood diseases that are discussed here. Unfolded proteins are guided by molecular chaperones folding them in to its native state. Whereas some of the mutations lead to the generation of misfolded proteins whose study is difficult as aggregation properties in the cell differ by type of fusion proteins used .So, continuous effort is being made in this area and the results are promisive but, as most of the proteins contain un organised regions of 30 amino acids which is necessary for non specific interactions with proteins. So, as protein -protein interactions play a major role, designing therapeutic drugs pertaining to protein -protein interactions is found to be useful.

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