Juniper Publishers Annals of Reviews and Research

Juniper Publishers- Open Access Journal of Annals of Reviews & Research   Bilateral Herpes Simplex Keratitis Presenting as Bilateral Ulcerative Blepharo-Keratoconjunctivitis: A Rarity or Pattern- Juniper Publishers   Authored by CharlesS Zwerling Abstract We report a case of an immunocompetent 77-year-old Caucasian female presenting with bilateral herpes simplex keratitis masquerading as bilateral ulcerative blepharo-keratoconjunctivitis. Most cases of herpes simplex keratitis present unilaterally and uncommon occurrences of bilateral cases range from 1.3% to 10.9%. In literature, bilateral herpes simplex keratitis has been reported for patients with atopic disease, corticosteroid use, autoimmune diseases, and UV A light exposure. Our patient had none of these conditions, but she did suffer from type 2 diabetes mellitus that was well-controlled. She had no prior history of known herpes simplex disease and tested negative for COVID 19. To date, this is the third...

  Juniper Publishers- Open Access Journal of Annals of Reviews & Research Upcoming New Drug Therapies for Nocturia - A Nonsystematic Stepwise Review- Juniper Publishers Authored by King C Lee Abstract Current treatment options for nocturia are unsatisfactory, prompting review of clinical studies of potential new and better drug therapies for nocturia. A 3-step nonsystematic review was performed. Step 1 was to review articles related to nocturia in multiple databases. Step 2 was to review articles identified in Step 1 for potential new and better drug therapies for nocturia. Step 3 was to review the websites of companies sponsoring new drug therapies. Two categories of potential new drugs were identified. Category 1 drugs include new drugs, new drug combinations, or new routes of administration of drugs that are in the existing class for nocturia. They are: (a) demospressin combined with tamsulosin (an alpha-1 blocker), solifenacin (an antimuscarinic), or furosemid...

  Juniper Publishers- Open Access Journal of Annals of Reviews & Research A Case Report of Family with Congenital Non-Syndromic Hearing Loss (NSHL) with Variants of Uncertain Significance (VUS) in GATA3 and COLA43 Genes- Juniper Publishers Authored by Venkateshwari Ananthapur Abstract Objectives: Hearing impairment is the frequent sensory deficit in human populations. Non-syndromic hearing loss accounts for 70%, with autosomal recessive, autosomal dominant, X linked and mitochondrial mode of inheritance. The case report represents a family with two siblings having congenital non-syndromic hearing loss (NSHL), and mother with acquired deafness. The objective of the case report was to identify the gene mutations resulting in NSHL in the family. Methods: Next generation sequencing (NGS) based deafness gene panel was used to identify the gene variants in the family. Results: Next generation sequencing (NGS) based deafness gene panel results identified variant of un...