Pharmacological Modulation of Long Cardiac QT Interval in Ex Vivo and In Vitro Experimental Models- Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF REVIEWS & RESEARCH Pharmacological Modulation of Long Cardiac QT Interval in Ex Vivo and In Vitro Experimental Models Authored by Maria Consiglia Trotta Abstract Prolongation of cardiac QT interval is one of the most dangerous consequences of hyperglycemia, acting on accumulation of reactive oxygen species and impairment of ionic pumps. Previous studies showed that the selective inhibition of the endogenous aldose reductase 2 (ALR2) activities, responsible of the oxidative heart damage following diabetes, could be a therapeutic treatment for the high glucose-related cardiac alterations. Indeed, the newly synthetized ALR2 inhibitor, the benzofuroxane derivative 5(6)-(benzo[d]thiazol-2-ylmethoxy)benzofuroxane (BF-5m), dose-dependently reduced the long cardiac QT interval in isolated rat hearts perfused with high glucose, by increasing in parallel the expression and activity of endogenous antioxidant pathways and ...