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Pharmacological Modulation of Long Cardiac QT Interval in Ex Vivo and In Vitro Experimental Models- Juniper Publishers

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JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF REVIEWS & RESEARCH Pharmacological Modulation of Long Cardiac QT Interval in Ex Vivo and In Vitro Experimental Models Authored by Maria Consiglia Trotta Abstract Prolongation of cardiac QT interval is one of the most dangerous consequences of hyperglycemia, acting on accumulation of reactive oxygen species and impairment of ionic pumps. Previous studies showed that the selective inhibition of the endogenous aldose reductase 2 (ALR2) activities, responsible of the oxidative heart damage following diabetes, could be a therapeutic treatment for the high glucose-related cardiac alterations. Indeed, the newly synthetized ALR2 inhibitor, the benzofuroxane derivative 5(6)-(benzo[d]thiazol-2-ylmethoxy)benzofuroxane (BF-5m), dose-dependently reduced the long cardiac QT interval in isolated rat hearts perfused with high glucose, by increasing in parallel the expression and activity of endogenous antioxidant pathways and ...

Juniper Publishers: Internet Computerized Adaptive Testing to Detect C...

Juniper Publishers: Internet Computerized Adaptive Testing to Detect C... : Psychologyand Behavioral Science International Journal   Juniper Publishers Abstract Objective:  Surveys are often conducted but rar...

Juniper Publishers: Prostate Volume, Size Does Matter. Growth Dynamics...

Juniper Publishers: Prostate Volume, Size Does Matter. Growth Dynamics... : JOJ Urology & Nephrology     Juniper Publishers Abstract Background:  Analysis of prostatic growth has focused on the whole glan...

Twenty-Seven Steps to a Paper Tape! - Juniper Publishers

JUNIPER PUBLISHERS- OPEN ACCESS JOURNAL OF REVIEWS & RESEARCH Twenty-Seven Steps to a Paper Tape! Authored by Murali Chemuturi Opinion Do you remember paper tape? It was used in NC (Numerically Controlled) machines of 80s and 90's of the 20th century. I remember them. In the 80's I worked in an electronics manufacturing company. It had many divisions manufacturing different classes of products. I was working in a division producing control systems for flow-process type of manufacturing organizations like fertilizers, chemicals, atomic reactors and so on. That company had one division manufacturing computer systems too. A new type of control equipment had to be manufactured for a customer. This product had a set of densely populated components. Each component had a number of pins around which wire had to be wrapped tightly using a wire-wrapping gun. The wire had to be drawn straight so that it is as short as possible, for technical reasons. Routi...